Substrate: CD95 antigen (Cell surface receptor)
Seq-ID: P25445 [Homo sapiens]
Download:fasta csv
Interaction Network(s):
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-18737   FADD_HUMAN
MINT-4055317   CASP8_HUMAN
MINT-4085360   FYN_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
identical protein binding,
transmembrane receptor activity,
kinase binding		 extracellular region,
death-inducing signaling complex,
cytosol,
integral to membrane,
soluble fraction		 positive regulation of necrotic cell death,
induction of apoptosis by extracellular signals,
protein complex assembly,
anti-apoptosis,
immune response,
activation of pro-apoptotic gene products
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
Y 91 DCVPCQEGKEYTDKAHFSSKC - 17195092
LTP
1.00
 - TNFR
0.11
 --
Y 91 DCVPCQEGKEYTDKAHFSSKC - 15660394
LTP
1.00
 - TNFR
0.11
 --
S 209 CRKHRKENQGSHESPTLNPET - 18669648
HTP
0.82
 - -
0.63
 --
S 212 HRKENQGSHESPTLNPETVAI - 18669648
HTP
1.00
 - -
0.60
 --
T 214 KENQGSHESPTLNPETVAINL - 18669648
HTP
0.07
 - -
0.56
 --
T 219 SHESPTLNPETVAINLSDVDL - 18669648
HTP
0.17
 - DEATH
0.41
 --
Y 232 INLSDVDLSKYITTIAGVMTL - 17195092
LTP
1.00
 - DEATH
0.16
 3EZQ 40.61%
Y 232 INLSDVDLSKYITTIAGVMTL - 15660394
LTP
1.00
 - DEATH
0.16
 3EZQ 40.61%
Y 291 WHQLHGKKEAYDTLIKDLKKA - 17195092
LTP
0.97
 Fyn SH2;
INPP5D SH2		 DEATH
0.33
 3EZQ 62.45%
Y 291 WHQLHGKKEAYDTLIKDLKKA - 15660394
LTP
0.97
 Fyn SH2;
INPP5D SH2		 DEATH
0.33
 3EZQ 62.45%

Substrate: CD95 antigen (Cell surface receptor)
Seq-ID: P25446 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-4085294   EZRI_MOUSE
MINT-4085319   CASP8_MOUSE
MINT-4085334   FADD_MOUSE
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
extracellular region,
external side of plasma membrane,
integral to membrane		 immunoglobulin production,
inflammatory cell apoptosis,
regulation of myeloid cell differentiation,
negative regulation of apoptosis,
negative regulation of B cell activation,
response to protein stimulus,
response to toxin,
gene expression,
regulation of lymphocyte differentiation,
B cell mediated immunity,
induction of apoptosis via death domain receptors,
protein homooligomerization,
response to glucocorticoid stimulus,
negative thymic T cell selection,
spleen development,
activation-induced cell death of T cells,
transformed cell apoptosis,
renal system process
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
T 206 KRRQDDPESRTSSRETIPMNA - 19144319
HTP
0.08
 - -
0.65
 - medium
S 220 ETIPMNASNLSLSKYIPRIAE - 17242355
HTP
0.17
 - DEATH
0.36
 - medium
S 220 ETIPMNASNLSLSKYIPRIAE - 19144319
HTP
0.17
 - DEATH
0.36
 - medium
S 222 IPMNASNLSLSKYIPRIAEDM - 19144319
HTP
1.00
 - DEATH
0.36
 - medium
T 314 DMVQKDLGKSTPDTGNENEGQ - 19144319
HTP
0.02
 - -
0.70
 - medium

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